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The nervous system lesions which may be treated in a patient including human mammalian patients and non-human according to the methods of the invention include, among others, the following lesions of the central nervous system including the spinal cord, brain or peripheral. Immune responses antiparasitic that may be enhanced using fusion proteins albumin of the invention as an adjuvant include parasite and diseases or symptoms 5 associated with parasites can be used as adjuvant to enhance an immune response described herein or otherwise known in The technique.
Fusion proteins albumin can also be modified with a detectable label such as an enzyme 35, fluorescent, isotopic or affinity label to allow for detection and isolation of the protein. Y” provides the amino acid sequence of the full length albumin fusion protein of the invention.
The albumin fusion proteins and the invention can also be detected in vivo by imaging. The albumin fusion proteins of the invention can be used in one or more of the applications described herein 25, and may apply to veterinary medicine. Fusion proteins albumin of the invention can stimulate proliferation of endothelial cells, keratinocytes, and basal keratinocytes.
Polypeptides may be branched as a result of, for example, ubiquitination, humwdo they may be cyclic, with or without branching.
For example, can be produced isomers glycosylation seci annulling or introducing glycosylation sites, for example by substitution or deletion of amino acid residues, such as substitution of glutamine for asparagine, or produced recombinant non-glycosylated proteins by expressing proteins in host cells not glycosylated, for example in E. The HA fragment is the mature form of HA. Surgical meshes can be used which have been coated hu,edo anti-angiogenic compositions of the present invention in any procedure wherein a surgical mesh may be used.
ES2500918T3 – Albumin fusion proteins and beta interferon – Google Patents
The nervous system disorders that can be treated with the compositions of the invention p. You know the parameters that can be modified to increase the signal detected and to reduce the background noise a skilled artisan.
These molecules 25 could also be used to treat disorders. Many therapeutic proteins are very labile in their unfused state.
Other complexes suitable tungsten and molybdenum complexes include hydroxo of derived derivatives, for example, glycerol, tartaric acid and sugars. A fusion protein albumin of the invention can also be used to prevent skin aging sunburn by stimulating keratinocyte growth.
Humeo of Table 1 comprising administering to a patient in which desired such treatment, prevention or amelioration a fusion protein of albumin of the invention comprising a therapeutic protein or a portion corresponding to a therapeutic protein or fragment or variant thereof disclosed in a column “therapeutic protein: An advantage of glutamine synthase based vectors is the availability of cell lines p.
As used herein, “albumen” refers collectively to albumin protein or amino acid sequence having one or more functional activities p.
Hjmedo practices have been proposed to storage problems of labile protein molecules solutions. Hormones secreted by the glands of seeco endocrine system control physical growth, sexual function, metabolism, kmpetigo other functions. Viruses are one example of an infectious agent that can cause disease or symptoms that can be treated or detected by albumin fusion proteins of the invention.
The host may be a human.
In a specific embodiment where the compound of the invention is a nucleic acid encoding a protein, the nucleic acid may be administered in vivo to stimulate expression of its encoded protein, by constructing 40 as part of an expression vector nucleic acid suitable and manage so that it becomes intracellular, for example by use of a retroviral vector see U.
The radiometal ion associated with the macrocyclic chelator may be 90Y. A fusion protein albumin of the invention may also increase or decrease the differentiation or proliferation of embryonic stem cells, besides, as discussed above, hematopoietic lineage Complejos de molibdenilo adecuados incluyen, por ejemplo, acetilacetonato de molibdenilo.
As liquid carriers can be employed saline solutions and aqueous dextrose and glycerol, particularly for injectable solutions.
The present invention also relates to vectors containing a polynucleotide encoding a fusion protein of albumin of the present invention, host cells and production of albumin fusion proteins by synthetic and recombinant techniques.
Full text of “Boletín de la Asociación Médica de Puerto Rico”
The albumin fusion proteins of the invention can be used adjuvant to enhance anti-parasitic immune responses. The fusion proteins of the invention enhance albumin antigen presentation or antagonize eeco presentation in vitro or in vivo antigen.
Complejos de vanadilo adecuados incluyen, por ejemplo, acetilacetonato de vanadilo y sulfato de vanadilo, incluyendo hidratos de sulfato de vanadilo tales como mono y trihidratos de humsdo dde vanadilo. Such compositions comprise a therapeutically effective amount of a compound and a pharmaceutically acceptable carrier.
Topical therapy may also be useful prophylactically in corneal lesions which are known to have a high probability of inducing an angiogenic response such as chemical burns.
Diseases of the heart valves include, among others, failure of the aortic valve stenosis 40 aortic valve, heart murmurs, prolapse aortic valve prolapse mitral valve prolapse tricuspid valve insufficiency of the mitral valvemitral valve stenosis, pulmonary atresia, pulmonary valve insufficiency, pulmonary valve stenosis, tricuspid atresia, tricuspid valve insufficiency, and tricuspid valve stenosis.
In addition, fusion proteins of the invention could be used to treat or prevent the onset of diabetes mellitus. Similarly, a fusion protein of albumin can be used to modulate mammalian metabolism affecting catabolism, anabolism, processing, use and energy storage.
When the therapeutic protein portion of the fusion protein albumin is an analogue, variant or, on the other hand, is altered or does not include the complete sequence for that protein, the prolongation of therapeutic activity may be compared, as an alternative, with the unfused equivalent of that analog, variant, altered peptide or incomplete sequence Fusion proteins albumin of the invention could stimulate proliferation and differentiation of hepatocytes and, thus, could be used to alleviate or treat liver diseases and pathologies such com fulminant liver failure caused by cirrhosis, liver damage caused by viral hepatitis and substances toxic i.
Fusion proteins albumin of the invention can be used as antigen for gneracion antibody to inhibit or enhance immune responses against polypeptides of the invention.