FORMULASI SUSPENSION PDF

Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

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According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market. All other chemicals were purchased fromMerck, Darmstadt, Germany.

Results From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1. For suspension formulation equivalent to mg of cefuroxime was suspended in 5 ml vehicle, after selecting the type and concentration of wetting agent, other ingredients such as flocculating agents, suspending agents, preservatives and flavors were added.

The charge of the particles effects their distribution in the environment and increases the concentration of opposite charge on the surface close to them which produces electric double layer.

The stability of the amorphous form of cefuroxime axetil in solid state. Quantity of zeta potential can indicate the potential stability of the colloidal system, if the formu,asi have a large positive or negative zeta potential they will have a tendency to repel each other and in too low zeta potentials particles will accumulate and attract each other.

Also the system was found to be time-depended. Support Center Support Center. Then using equation derived from calibration curve. One of the methods for making the suspension, is the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: After selecting the acceptable preparations, physical stability tests and other tests such as dissolution rate, pH, zeta potential and viscosity measurement of formulations were performed.

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Conflict of interest The authors report no conflicts of interest.

Please review our privacy policy. Eur J Pharm Biopharm. An advantage of cefuroxime over other second-generation cephalosporins is that it is effective in the treatment of Neisseria gonorrhea and H influenzae. Tabibi S, Usspension CH. According to the viscosity curves, the suspensions were pseudo plastic, i.

Considering no sedimentation, the sedimentation volume was determined to be 1.

Table 1 Composition of selected formulations designed in Minitab ver. Formulation of suspensions One of the methods for making the suspension, formuladi the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: In Figure 1 the percentage of release in all the formulations are presented.

Other tests, including measurement of pH, viscosity and zeta potential measurements were performed and finally the best formulations were selected.

Wuspension online Dec Port City Press; It is characterized by being the only second-generation cephalosporin which adequately penetratesinto the cerebrospinal fluid CSF.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

The degrees of flocculation were also equal to 1. According to these properties a general discussion is presented. Evaluation of physical stability Made formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the original volume of the suspension and degree suspennsion flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

Formmulasi criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability. Influence of the soluble solids on the zeta potential of the cloudy formmulasi juice.

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The authors would like to thank Dana Pharmaceutical Co.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

A new approach to HPLC analysis of medicinal suspensions. For the assay solution 5 ml of suspension was dissolved in 50 ml methanol and after shaking for 5 minutes ml of medium was added and after achieving Pharmacokinetic models for the saturable absorption of cefuroxime axetil and saturable elimination of cefuroxime axetil. Conclusion According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market.

Percent of labeled amount. This article has been cited by other articles in PMC. Percentage of release for all selected formulations. Dissolution test For 3 shspension each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes. Author information Article notes Copyright and License information Disclaimer.

Open in a separate window. Considering the differences of the viscosity in up and down curves the thixotropy of the system is obvious so the vehicle was pseudo plastic and thixotrop. Remington the science and practice of Pharmacy.

Acknowledgement The authors would like to thank Dana Pharmaceutical Co. The potential of the moving layer around each particle is called zeta potential. Oral route is the selective method for administration of most of the drugs. J Pharm Biomed Anal.